The Laboratory of Nanomedicine and Immunoengineering was established in the fall of 2019 at the University of Kentucky. Our research spans across the expansive domains of nanobiotechnology, genome editing, immunoengineering, and cancer therapy. With a focus on interdisciplinary collaboration and the integration of state-of-the-art methodologies, we strive to unravel the mysteries of disease processes and design targeted interventions that hold promise for transformative medical breakthroughs.

Representative publications:

  • Zhongchao Yi, Xiaoyue Yang, Ying Liang, Fanny Chapelin, and Sheng Tong. Enhancing ROS-inducing nanozyme through intraparticle electron transport. Small, 2023.

  • Sheng Tong*, Buhle Moyo*, Ciaran M. Lee, Kam Leong, and Gang Bao. Engineered materials for in vivo delivery of genome editing machinery. Nature Reviews Materials, 4, 726-737, 2019.

  • Haibao Zhu*, Linlin Zhang*, Sheng Tong*, Ciaran Lee, Harshavardhan Deshmukh, and Gang Bao. Spatial control of in vivo CRISPR/Cas9 genome editing via nanomagnets. Nature Biomedical Engineering. 3, 126-136, 2019.

  • Sheng Tong, Christopher Quinto, Priya Mohindra, Linlin Zhang, and Gang Bao. Size-Dependent heating of magnetic iron oxide nanoparticles. ACS Nano, 11, 6808-6816, 2017.

  • Yongzhi Qiu*, Sheng Tong*, Linlin Zhang, Yumiko Sakurai, David R. Myers, Lin Hong, Wilbur Lam, and Gang Bao. Magnetic forces enable controlled drug-delivery by disrupting endothelial cell-cell junctions. Nature Communication, 8, 15994, 2017.

  • Sheng Tong, BinBin Ren, Zhilan Zheng, Han Shen, and Gang Bao. Tiny grains give huge gains – nanocrystal-based signal amplification. ACS Nano, 7, 5142-5150, 2013.

  • Sheng Tong*, Sijian Hou*, Binbin Ren, Zhilan Zheng, and Gang Bao. Self-assembly of phospholipid-PEG coating on nanoparticles through dual solvent exchange. Nano Letters. 11, 3720-3726, 2011.

For more information, see Research and Publications.