Our laboratory develops engineering approaches to control the delivery and activity of therapeutics in vivo. We integrate nanotechnology, genome engineering, biomaterials, and immunoengineering to overcome key barriers in therapeutic delivery. Current research focuses on spatially controlled genome editing and cancer immunotherapy, engineered extracellular vesicles for targeted delivery, and magnetic nanotechnologies that regulate biological processes.
Laboratory of Nanomedicine & Immunoengineering Engineering nanoscale systems for spatially controlled therapy
Engineering precision in medicine
Research
Spatially Controlled Genome Editing
We engineer delivery systems that restrict genome-editing activity to defined anatomical sites, enabling localized genome editing and cancer immunotherapy while limiting activity in healthy tissues.
Engineered Extracellular Vesicles
We develop scalable strategies to engineer biological vesicles for targeted delivery of nucleic acids, proteins, and genome-editing machinery across challenging biological barriers.
Magnetic Nanomedicine
We investigate how nanoscale magnetic forces and heating interact with biological systems and harness these mechanisms for targeted delivery, cellular regulation, and therapeutic intervention.
Featured Research
Conceptual illustration of magnetically controlled, spatially restricted genome editing, adapted from our bioRxiv preprint.
Latest Highlights
New NIH R01 supports spatially controlled genome editing
A new NIDCR-funded project will develop magnetically controlled genome-editing strategies for localized head and neck cancer therapy.
Magnetic nanoparticle heating
A new Nano Letters study reveals how nanoscale magnetic switching governs multiscale heating behavior.
NIH TARGETED Challenge
ARENEX was selected as a Phase I winner for developing nonviral genome-editor delivery technologies.
Selected Publications
Spatial control of genome editing activity enables localized immunotherapy
bioRxiv, 2026
Spatially controlled genome editing for localized cancer immunotherapy.
Nanoscale magnetic switching governs multiscale heating in magnetic nanoparticles
Nano Letters, 2026
Mechanistic insights into magnetic nanoparticle heating across size scales.
Spatial control of in vivo CRISPR/Cas9 genome editing via nanomagnets
Nature Biomedical Engineering, 2019
Magnetically controlled spatial genome editing in vivo.
Engineered materials for in vivo delivery of genome editing machinery
Nature Reviews Materials, 2019
Engineering principles for therapeutic genome-editor delivery.